Hypothetical Relationship between Positive Thoughts and Genetics

Symbolic representation:

\[ G(t) = \int_{0}^{t} P(\tau) \,d\tau \]

This rudimentary equation represents the cumulative effect of positive thoughts (\(P(t)\)) on genetics (\(G(t)\)) over time (\(t\)).

Of course, this formulation needs to be specified. This means that specific genetic traits associated with health and longevity should be tested. DNA modifications, DNA methylation, histone methylation, histone acetylation and DNA damage can lead towards apoptosis and should therefore be considered (cf. telomeres and telomerase activity) . The role of pathways involved in the regulation of lifespan such as DAF-16/FOXO (forkhead box protein O1), TOR and JNK pathways should also be taken into account, inter alia.

Figure 1: Regulatory role of SRT1 signaling in the cell. SIRT1, an NAD-dependent deacetylase affects several downstream molecules and promotes life. Sirt1 based downregulation of apoptosis and inflammation leads to the extension of lifespan contrary to that enhanced lipid metabolism and insulin sensitivity are main factors that increase the lifespan. As the discussion included the sirt1 gene and we have a separate section for the associated pathways, Figure 1 was meant to indicate the central role of sirt1 gene in the cellular and metabolic pathways involved in the extended lifespan. Green colour indicates final process regulated, downward and upward arrows indicate downregulation and upregulation of process.
Figure 2: Proposed mechanistic role of DNA methylation, histone methylation and histone acetylation in the regulation of lifespan in the human and other species. Upward and downward arrows indicate upregulation and downregulation of specific genes of processes. Some major aspects have been highlighted by specific colours.


Figure 3: Role of DNA damage repair system in the longevity of lifespan. Successful DNA repair leads to the continuation of life activity/cell division, contrary to that failure in the DNA repair promotes programmed cell death (apoptosis). Direction of arrows indicate upregulation or downregulation of a process.

Bin-Jumah, M. N., Nadeem, M. S., Gilani, S. J., Al-Abbasi, F. A., Ullah, I., Alzarea, S. I., Ghoneim, M. M., Alshehri, S., Uddin, A., Murtaza, B. N., & Kazmi, I. (2022). Genes and Longevity of Lifespan. International journal of molecular sciences, 23(3), 1499. https://doi.org/10.3390/ijms23031499